The iGEM competition is a prestigious international event that draws over 400 teams from 60 countries annually, including renowned institutions. It is the most well-known Synthetic Biology competition for students, providing a platform for participants to pursue their passion for synthetic biology and share innovative ideas with other teams. The competition aims to develop an open community and enhance collaboration with other universities. The Polyneer team from PolyU joined iGEM for the first time, aiming to make a positive impact on the world by focusing on solving the issue of acquired resistance of non-small cell lung carcinoma to EGFR-targeted therapy. After nearly a year of hard work, the team was awarded a "silver medal" among the more than 400 teams, making their efforts worthwhile.