From Challenge to Breakthrough: Advancing HCC Treatment

Kenneth developed a deep understanding of HCC, recognizing it as the most common form of liver cancer and a major global health issue. He learned about its prevalence (sixth most diagnosed cancer, third leading cause of cancer deaths), unique biological traits, and the challenges in treating it, especially as the disease progresses and treatment options become limited.

A central focus of Kenneth’s research is understanding why HCC becomes resistant to therapies, such as chemotherapy. He explored how some patients initially respond to treatment but later relapse, leading to poor prognosis. His work aims to uncover the molecular and cellular mechanisms behind this resistance, which is crucial for developing more effective treatments.

Kenneth investigated the protein transcobalamin 1 (TCN1), a vitamin B12-binding protein found in blood and salivary glands. He learned that TCN1 is highly expressed in drug-resistant HCC cells and is relatively understudied in cancer biology. His research explores the potential role of TCN1 in HCC progression and resistance, opening new avenues for therapeutic targeting.

Kenneth gained hands-on experience with a range of experimental techniques, including in vivo mouse models and molecular biology methods. He learned how to design, execute, and refine experiments to dissect tumor biology, and how to use animal facilities and advanced lab equipment to support his research.

Kenneth’s research equipped him with knowledge about designing combinational therapies for HCC, including the integration of immunotherapy to overcome tumor immunosuppression. He understands the importance of targeting multiple pathways and mechanisms to break through resistance and improve patient outcomes, contributing to smarter and more effective cancer treatments.

Kenneth describes repeatedly facing failed experiments and the need to redo them, sometimes working weekends to ensure progress. He learned to build resilience, cope with setbacks, and bounce back from failures—an essential lifelong skill for any researcher or professional, as it enables continuous growth despite challenges.

Adapting to the research lab environment required Kenneth to manage his time effectively, balancing literature reviews, coursework, and experimental work. He learned to utilize his time efficiently, which is crucial for meeting deadlines, maintaining productivity, and achieving long-term goals in both academic and professional settings.

Kenneth’s story highlights the importance of working with supervisors, lab members, and technical staff. He benefited from a collaborative environment where team members shared expertise and supported each other. This skill is vital for lifelong learning, as collaboration fosters knowledge exchange, problem-solving, and innovation.

Initially shy and nervous about speaking, Kenneth improved his communication skills through lab meetings, conferences, and symposiums. He learned to present his research clearly to different audiences, gaining confidence and the ability to tailor his message—skills that are invaluable for sharing knowledge and advancing in any career.

Kenneth transitioned from theoretical learning to hands-on experimentation, refining protocols and learning new techniques as needed. He sought advice from others and adapted his approach when direct answers weren’t available. This openness to learning and ability to modify methods is a key lifelong skill, ensuring ongoing personal and professional development.